Magnesium - Journal of Research and Experiential Medicine

Because magnesium is used in enzymes and many other places in the body, treating a nutritional deficiency of magnesium puts a person at risk of treating other conditions at the same time, causing medications for clotting, blood pressure, diabetes, and other conditions to potentially become too strong.

Medical monitoring for people who are taking any medication is absolutely critical.

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Twenty years of research has not awakened much of the psychiatric community to the benefits of magnesium supplementation for a significant number of people with depression and neuroses. Undiagnosed deficiencies and sometimes undiagnosable insufficiencies by standard testing (when the body has created a coping mechanism which leaves the levels correct in the serum at the expense of the cells) cause some depression, through shorting magnesium from neurotransmitters such as glutathione.

If there is no shortage, there is likely to be no benefit. Likewise, where there is a benefit, there is likely an undiagnosed deficiency or insufficiency.

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Magnesium in neuroses and neuroticism

https://www.ncbi.nlm.nih.gov/books/NBK507254/

Uwe Gröber's Magnesium and Drugs, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539869/#!po=62.5000 with an excellent image of ways that drug interfere with nutrient levels in the body, and a table specific to Magnesium.

Lists arterial calcification, hypertension, insulin resistance, atherosclerosis, heart failure, and thrombosis, and describes disorders of magnesium metabolism as a principal, under-recognized, "driver" of cardiovascular disease

There must be attention when adding magnesium for patients taking multiple medications, in case the conditions described above improve, so their medications can be reduced accordingly.

An excellent image of how drugs interfere with nutrient levels, in Uwe Gröber's Magnesium and Drugs:
[https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=6539869_ijms-20-02094-g001.jpg] There is also a table specific to interference with magnesium levels.

Magnesium deficiency inhibits biosynthesis of blood glutathione and tumor growth in the rat

Proc Soc Exp Biol Med. 1986 Mar;181(3):326-32.

doi: 10.3181/00379727-181-42260.

Authors: B J Mills, R D Lindeman, C A Lang

PMID: 3945642

DOI: 10.3181/00379727-181-42260

https://pubmed.ncbi.nlm.nih.gov/7062145/

Role of magnesium in glutathione metabolism of rat erythrocytes

PubMed

J Nutr. 1982 Mar;112(3):488-96.

doi: 10.1093/jn/112.3.488.

Authors: J M Hsu, B Rubenstein, A G Paleker

PMID: 7062145

DOI: 10.1093/jn/112.3.488

https://pubmed.ncbi.nlm.nih.gov

Magnesium-deficient diet alters depression- and anxiety-related behavior in mice—influence of desipramine and Hypericum perforatum extract.

https://www.sciencedirect.com/science/article/abs/pii/S0028390804002588

Not only did the magnesium-depleted mice involved display depression and anxiety symptoms under specific tests, but antidepressants were able to control the symptoms.

Magnesium and major depression

https://www.ncbi.nlm.nih.gov/books/NBK507265/

Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487054/

A Synergistic Effect of a Daily Supplement for 1 Month of 200 Mg Magnesium Plus 50 Mg Vitamin B6 for the Relief of Anxiety-Related Premenstrual Symptoms: A Randomized, Double-Blind, Crossover Study

M C De Souza et al. J Womens Health Gend Based Med. 2000 Mar.

http://www.ncbi.nlm.nih.gov/pubmed/10746516

Rapid Recovery From Major Depression Using Magnesium Treatment

http://www.ncbi.nlm.nih.gov/pubmed/16542786

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Drugs that Deplete: Magnesium

http://pennstatehershey.adam.com/content.aspx?productid=107&pid=33&gid=000711

https://www.stlukes-stl.com/health-content/medicine/33/000711.htm

Magnesium and Drugs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539869/

Medications that Deplete Magnesium

https://www.google.com/amp/s/blog.livonlabs.com/vitamins-and-nutrients/magnesium/medications-that-deplete-magnesium/amp/

(Below from links at bottom of The Placebo Effect, Antioxidants and Neurochemistry on this site; may be repeats.)

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Magnesium and clotting, regarding post-stroke depression:

Effect of magnesium on fibrin formation from lower molecular weight (LMW) fibrinogen

https://pubmed.ncbi.nlm.nih.gov/11153893/

Lipinski B, Lipinska I. Effect of magnesium on fibrin formation from lower molecular weight (LMW) fibrinogen. Magnes Res. 2000;13(4):233-237.

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References regarding magnesium and depression:

From: Aging and Disease

JKL International LLC

Association between Serum Magnesium Levels and Depression in Stroke Patients

Aging Dis. 2016 Dec; 7(6): 687–690.

Published online 2016 Dec 1. doi: 10.14336/AD.2016.0402

PMCID: PMC5198859

PMID: 28053818

Yingying Gu, Kai Zhao, Xiaoqian Luan, Zhihua Liu, Yan Cai, Qiongzhang Wang, Beilei Zhu,* and Jincai He*

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198859/

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Magnesium and major depression

Eby GA, Eby KL, Murk H.

https://www.ncbi.nlm.nih.gov/books/NBK507265/#_NBK507265_pubdet_

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Role of magnesium supplementation in the treatment of depression: A randomized clinical trial

PLoS One. 2017; 12(6): e0180067.

Published online 2017 Jun 27. doi: 10.1371/journal.pone.0180067

PMCID: PMC5487054

PMID: 28654669

Emily K. Tarleton,#1,* Benjamin Littenberg,#1,2 Charles D. MacLean,1,2,‡ Amanda G. Kennedy,1,2,‡ and Christopher Daley3,‡

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487054/

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Case Reports

Rapid recovery from major depression using magnesium treatment

George A Eby et al. Med Hypotheses. 2006.

Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-370. doi:10.1016/j.mehy.2006.01.047

https://pubmed.ncbi.nlm.nih.gov/16542786/

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Magnesium for treatment-resistant depression: a review and hypothesis.

Eby GA 3rd, et al. Med Hypotheses. 2010. PMID: 19944540 Review.

Eby GA 3rd, Eby KL. Magnesium for treatment-resistant depression: a review and hypothesis. Med Hypotheses. 2010;74(4):649-660. doi:10.1016/j.mehy.2009.10.051

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Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response

Beata Ryszewska-Pokraśniewicz, Anna Mach, [...], and Maria Radziwoń-Zaleska

Nutrients. 2018 Aug; 10(8): 1014.

Published online 2018 Aug 3. doi: 10.3390/nu10081014

PMCID: PMC6115747

PMID: 30081500

Beata Ryszewska-Pokraśniewicz,1 Anna Mach,2,* Michał Skalski,2 Piotr Januszko,2 Zbigniew M. Wawrzyniak,3 Ewa Poleszak,4 Gabriel Nowak,5,† Andrzej Pilc,5 and Maria Radziwoń-Zaleska2,†

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115747/

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Review

Magnesium in depression

Anna Serefko et al. Pharmacol Rep. 2013.

Pharmacol Rep. 2013;65(3):547-54.

doi: 10.1016/s1734-1140(13)71032-6.

Authors

Anna Serefko 1, Aleksandra Szopa, Piotr Wlaź, Gabriel Nowak, Maria Radziwoń-Zaleska, Michał Skalski, Ewa Poleszak

PMID: 23950577

DOI: 10.1016/s1734-1140(13)71032-6

Serefko A, Szopa A, Wlaź P, et al. Magnesium in depression. Pharmacol Rep. 2013;65(3):547-554. doi:10.1016/s1734-1140(13)71032-6

https://pubmed.ncbi.nlm.nih.gov/23950577/

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Magnesium and depression

Anna Serefko et al. Magnes Res. 2016.

Serefko A, Szopa A, Poleszak E. Magnesium and depression. Magnes Res. 2016;29(3):112-119. doi:10.1684/mrh.2016.0407

https://pubmed.ncbi.nlm.nih.gov/27910808/

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