Fibromyalgia citations
Backup from QuickMemo: 27 June2021: new at top.
Tecchio F, Assenza G, Zappasodi F, Mariani S, Salustri C, Squitti R. Glutamate-mediated primary somatosensory cortex excitability correlated with circulating copper and ceruloplasmin. Int J Alzheimers Dis. 2011;2011:292593. doi: 10.4061/2011/292593. Epub 2011 Nov 21. PMID: 22145081; PMCID: PMC3227495.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227495/
https://www.hindawi.com/journals/ijad/2011/292593/
Bramwell B, Ferguson S, Scarlett N, Macintosh A. The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial. Altern Med Rev. 2000 Oct;5(5):455-62. PMID: 11056415.
https:// ???
The reduced sensitivity to pain and improvement in quality of life measured in this study appear to be clinically relevant and a larger, double-blind study is warranted.
Nazıroğlu M, Akkuş S, Soyupek F, Yalman K, Çelik Ö, Eriş S, Uslusoy GA. Vitamins C and E treatment combined with exercise modulates oxidative stress markers in blood of patients with fibromyalgia: a controlled clinical pilot study. Stress. 2010 Nov;13(6):498-505. doi: 10.3109/10253890.2010.486064. Epub 2010 Jul 28. PMID: 20666654.
https:// ???
In conclusion, VCE with EX may protect against FM-induced oxidative stress by up-regulation of an antioxidant redox system in the plasma and erythrocytes of patients with FM. Such protective effects of VCE in the patients seemed to be greater in combination with EX than EX alone
Ghandour, M.A., Hassan, A. & Ali, H.M. Voltammetric determination of copper with proton pump inhibitor drug omeprazole. J Anal Chem 70, 392–397 (2015). https://doi.org/10.1134/S1061934815030065
https://link.springer.com/article/10.1134/S1061934815030065
[2] Bianco, L.E., Wiesinger, J., Earley, C.J., Jones, B.C. Beard, J.L. Iron deficiency alters dopamine uptake and response to L‐DOPA injection in Sprague–Dawley rats. J of Neurochemistry 20 March 2008
https://doi.org/10.1111/j.1471-4159.2008.05358.x
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471-4159.2008.05358.x
Tecchio F, Assenza G, Zappasodi F, Mariani S, Salustri C, Squitti R. Glutamate-mediated primary somatosensory cortex excitability correlated with circulating copper and ceruloplasmin. Int J Alzheimers Dis. 2011;2011:292593. doi: 10.4061/2011/292593. Epub 2011 Nov 21. PMID: 22145081; PMCID: PMC3227495.
https:// elsewhere?
Irreversible inhibition is different from irreversible enzyme inactivation.
Jimenez K, Kulnigg-Dabsch S, Gasche C. Management of Iron Deficiency Anemia. Gastroenterol Hepatol (N Y). 2015 Apr;11(4):241-50. PMID: 27099596; PMCID: PMC4836595.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836595/
Anemia is associated with chronic fatigue, impaired cognitive function, and diminished well-being.
Park HY, Jeon HJ, Bang YR, Yoon IY. Multidimensional Comparison of Cancer-Related Fatigue and Chronic Fatigue Syndrome: The Role of Psychophysiological Markers. Psychiatry Investig. 2019 Jan;16(1):71-79. doi: 10.30773/pi.2018.10.26. Epub 2019 Jan 7. PMID: 30605994; PMCID: PMC6354035.
http://psychiatryinvestigation.org/journal/view.php?doi=10.30773/pi.2018.10.26
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354035/
Conclusion
Findings indicate that different pathophysiological mechanisms underlie CFS and CRF. Inflammatory marker and HRV may be potential biomarkers for distinguishing two fatigue syndromes and frontal EEG parameters may be quantitative biomarkers for CFS.
Keywords: Fatigue, Cancer, Biomarkers, Electrocardiography, Electroencephalography
INTRODUCTION
There is a high prevalence of cancer-related fatigue (CRF), which is prolonged fatigue after treatment for cancer, in this population [1]. However, the pathophysiological mechanisms underlying CRF are not yet clearly understood. Most criteria for CRF consist of core characteristics that include complaints of fatigue that result in functional impairments accompanied by cognitive and sleep disturbances [2,3]. These components overlap with the diagnostic criteria for chronic fatigue syndrome (CFS) [4], which is characterized by intense persisting fatigue that limits function. Thus, it has been proposed that similar mechanisms, including inflammation and perpetual deconditioning, underlie these two fatigue syndromes [5]. Still, the pathophysiology of CFS remains elusive, immune and neuroendocrine dysfunction and psychiatric disorders may be related to this disorder [6]. Additionally, central nervous system (CNS) abnormalities appear to be involved in the pathophysiology of CFS however, the results have been inconclusive [4].
Despite the similarities of these two fatigue syndromes, few studies have specifically compared them. Servaes et al. [5] reported that CFS patient exhibit a more severe degree of fatigue and pain than patients with CRF. Previous study reported the associations between cognitive function and the CRF [7] and CFS [8].
Fibro symptoms:
Goldenberg DL. Diagnosing Fibromyalgia as a Disease, an Illness, a State, or a Trait? Arthritis Care Res (Hoboken). 2019 Mar;71(3):334-336. doi: 10.1002/acr.23727. Epub 2019 Feb 6. PMID: 30724034.
https://onlinelibrary.wiley.com/doi/full/10.1002/acr.23727
-
Exercise:
Nazıroğlu M, Akkuş S, Soyupek F, Yalman K, Çelik Ö, Eriş S, Uslusoy GA. Vitamins C and E treatment combined with exercise modulates oxidative stress markers in blood of patients with fibromyalgia: a controlled clinical pilot study. Stress. 2010 Nov;13(6):498-505. doi: 10.3109/10253890.2010.486064. Epub 2010 Jul 28. PMID: 20666654.
-
Yoga massage stress anxiety social support & meditation
Adler-Neal AL, Zeidan F. Mindfulness Meditation for Fibromyalgia: Mechanistic and Clinical Considerations. Curr Rheumatol Rep. 2017 Sep;19(9):59. doi: 10.1007/s11926-017-0686-0. PMID: 28752493; PMCID: PMC5693231.
Fibromyalgia is chronic pain condition characterized by widespread “aching” pain and is often accompanied by tenderness in 18 pre-specified bodily locations [2]. It is often accompanied by sleep disturbances and fatigue [3, 4].
-
Arcos-Carmona IM, Castro-Sánchez AM, Matarán-Peñarrocha GA, Gutiérrez-Rubio AB, Ramos-González E, Moreno-Lorenzo C. Efectos de un programa de ejercicios aeróbicos y técnicas de relajación sobre el estado de ansiedad, calidad del sueño, depresión y calidad de vida en pacientes con fibromialgia: ensayo clínico aleatorizado [Effects of aerobic exercise program and relaxation techniques on anxiety, quality of sleep, depression, and quality of life in patients with fibromyalgia: a randomized controlled trial]. Med Clin (Barc). 2011 Oct 8;137(9):398-401. Spanish. doi: 10.1016/j.medcli.2010.09.045. Epub 2011 Feb 22. PMID: 21345470.
https://www.elsevier.es/es-revista-medicina-clinica-2-linkresolver-efectos-un-programa-ejercicios-aerobicos-S0025775310010444
Conclusions: The combination of aerobic exercise program and progressive relaxation techniques contribute to improve night rest, trait anxiety and quality of life in patients with fibromyalgia
-
Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014 Apr 16;311(15):1547-55. doi: 10.1001/jama.2014.3266. PMID: 24737367
-
Grey Matter Changes
Pomares FB, Funck T, Feier NA, Roy S, Daigle-Martel A, Ceko M, Narayanan S, Araujo D, Thiel A, Stikov N, Fitzcharles MA, Schweinhardt P. Histological Underpinnings of Grey Matter Changes in Fibromyalgia Investigated Using Multimodal Brain Imaging. J Neurosci. 2017 Feb 1;37(5):1090-1101. doi: 10.1523/JNEUROSCI.2619-16.2016. Epub 2016 Dec 16. PMID: 27986927; PMCID: PMC6596849.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596849/
https://www.jneurosci.org/content/37/5/1090.long
Chronic pain patients present with cortical gray matter alterations, observed with anatomical magnetic resonance (MR) imaging. Reduced regional gray matter volumes are often interpreted to reflect neurodegeneration, but studies investigating the cellular origin of gray matter changes are lacking.
-
Jezek M, Geilfus CM, Mühling KH. Glutamine synthetase activity in leaves of Zea mays L. as influenced by magnesium status. Planta. 2015 Dec;242(6):1309-19. doi: 10.1007/s00425-015-2371-8. Epub 2015 Jul 23. PMID: 26202737.
https://link.springer.com/article/10.1007/s00425-015-2371-8
Magnesium (Mg) is an integral component of the enzyme glutamine synthetase (GS), having both a structural and a catalytic role. Moreover, Mg is relevant for the post-translational regulation of the GS.
-
Iron deficiency:
Ortancil O, Sanli A, Eryuksel R, Basaran A, Ankarali H. Association between serum ferritin level and fibromyalgia syndrome. Eur J Clin Nutr. 2010 Mar;64(3):308-12. doi: 10.1038/ejcn.2009.149. Epub 2010 Jan 20. PMID: 20087382.
https://www.nature.com/articles/ejcn2009149
-
Substantiates one cause of psych w/fibro
Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH, Chen TJ, Bai YM. Association between psychiatric disorders and iron deficiency anemia among children and adolescents: a nationwide population-based study. BMC Psychiatry. 2013 Jun 4;13:161. doi: 10.1186/1471-244X-13-161. PMID: 23735056; PMCID: PMC3680022.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680022/
-
Depression low ferritin
The study implies a possible association between depression and decreased ferritin level before the occurrence of anemia.
Vahdat Shariatpanaahi, M., Vahdat Shariatpanaahi, Z., Moshtaaghi, M. et al. The relationship between depression and serum ferritin level. Eur J Clin Nutr 61, 532–535 (2007). https://doi.org/10.1038/sj.ejcn.1602542
https://www.nature.com/articles/1602542
-
Kim J, Wessling-Resnick M. Iron and mechanisms of emotional behavior. J Nutr Biochem. 2014 Nov;25(11):1101-1107. doi: 10.1016/j.jnutbio.2014.07.003. Epub 2014 Aug 2. PMID: 25154570; PMCID: PMC4253901.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253901/
Serotonin, dopamine & norepinephrine alterations low iron.
-
-
-
-
Gómez-Gómez ME, Zapico SC. Frailty, Cognitive Decline, Neurodegenerative Diseases and Nutrition Interventions. Int J Mol Sci. 2019 Jun 11;20(11):2842. doi: 10.3390/ijms20112842. PMID: 31212645; PMCID: PMC6600148.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600148/
-
Magnesium
Thomas J. Romano (Private Practice) & John W. Stiller (1994) Magnesium Deficiency in Fibromyalgia Syndrome, Journal of Nutritional Medicine, 4:2, 165-167, DOI: 10.3109/13590849409034552
https://www.tandfonline.com/doi/abs/10.3109/13590849409034552
Compared to reference laboratory and OA controls, FS patients had significantly lower RBC Mg levels. The plasma Mg levels of FS patients were no different than the reference laboratory or OA controls.
Need J&J&W et al to say RBC Mg means deficient to substantiate this.
Here!
Rude RK, Stephen A, Nadler J. Determination of red blood cell intracellular free magnesium by nuclear magnetic resonance as an assessment of magnesium depletion. Magnes Trace Elem. 1991-1992;10(2-4):117-21. PMID: 1844544.
https://pubmed.ncbi.nlm.nih.gov/1844544/
In 3 weeks from normal: These data suggest that determination of RBC Mg2+ may be used to reflect intracellular Mg status
-
Nuytten D, Van Hees J, Meulemans A, Carton H. Magnesium deficiency as a cause of acute intractable seizures. J Neurol. 1991 Aug;238(5):262-4. doi: 10.1007/BF00319737. PMID: 1919610.
-
Jezek M, Geilfus CM, Mühling KH. Glutamine synthetase activity in leaves of Zea mays L. as influenced by magnesium status. Planta. 2015 Dec;242(6):1309-19. doi: 10.1007/s00425-015-2371-8. Epub 2015 Jul 23. PMID: 26202737.
https://link.springer.com/article/10.1007/s00425-015-2371-8
Magnesium (Mg) is an integral component of the enzyme glutamine synthetase (GS), having both a structural and a catalytic role. Moreover, Mg is relevant for the post-translational regulation of the GS.
--
Botturi A, Ciappolino V, Delvecchio G, Boscutti A, Viscardi B, Brambilla P. The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients. 2020 Jun 3;12(6):1661. doi: 10.3390/nu12061661. PMID: 32503201; PMCID: PMC7352515.
Depression fibro
-z
Medical Hypotheses
Volume 140, July 2020, 109676
The art of suicidal molecular seduction for targeting drug resistance
Author links open overlay panelMohammad HassanMoshafiaArdavanAbiric1
Covalent inhibitors bind to their targets via a biologically permanent bound with their cognate receptor and therefore display more potent inhibiting characteristics. Suicide inhibitors or mechanism-based inhibitors are one of the covalent inhibitors, which require a pre-activation step by their targeting enzyme. This step accrues their selectivity and specificity with respect to other covalent inhibitors. After that pre-activation step, they produce an analogue of the transition state of the catalytic enzyme, which is practically incapable of dissociating from the enzyme.
--
Gómez-Gómez ME, Zapico SC. Frailty, Cognitive Decline, Neurodegenerative Diseases and Nutrition Interventions. Int J Mol Sci. 2019 Jun 11;20(11):2842. doi: 10.3390/ijms20112842. PMID: 31212645; PMCID: PMC6600148.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600148/
Not sure if needed
--
Martinc B, Grabnar I, Vovk T. Antioxidants as a preventive treatment for epileptic process: a review of the current status. Curr Neuropharmacol. 2014 Dec;12(6):527-50. doi: 10.2174/1570159X12666140923205715. PMID: 25977679; PMCID: PMC4428026.
Not needed?
Tecchio F, Assenza G, Zappasodi F, Mariani S, Salustri C, Squitti R. Glutamate-mediated primary somatosensory cortex excitability correlated with circulating copper and ceruloplasmin. Int J Alzheimers Dis. 2011;2011:292593. doi: 10.4061/2011/292593. Epub 2011 Nov 21. PMID: 22145081; PMCID: PMC3227495.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227495/
https://www.hindawi.com/journals/ijad/2011/292593/
Bramwell B, Ferguson S, Scarlett N, Macintosh A. The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial. Altern Med Rev. 2000 Oct;5(5):455-62. PMID: 11056415.
https:// ???
The reduced sensitivity to pain and improvement in quality of life measured in this study appear to be clinically relevant and a larger, double-blind study is warranted.
Nazıroğlu M, Akkuş S, Soyupek F, Yalman K, Çelik Ö, Eriş S, Uslusoy GA. Vitamins C and E treatment combined with exercise modulates oxidative stress markers in blood of patients with fibromyalgia: a controlled clinical pilot study. Stress. 2010 Nov;13(6):498-505. doi: 10.3109/10253890.2010.486064. Epub 2010 Jul 28. PMID: 20666654.
https:// ???
In conclusion, VCE with EX may protect against FM-induced oxidative stress by up-regulation of an antioxidant redox system in the plasma and erythrocytes of patients with FM. Such protective effects of VCE in the patients seemed to be greater in combination with EX than EX alone
Ghandour, M.A., Hassan, A. & Ali, H.M. Voltammetric determination of copper with proton pump inhibitor drug omeprazole. J Anal Chem 70, 392–397 (2015). https://doi.org/10.1134/S1061934815030065
https://link.springer.com/article/10.1134/S1061934815030065
[2] Bianco, L.E., Wiesinger, J., Earley, C.J., Jones, B.C. Beard, J.L. Iron deficiency alters dopamine uptake and response to L‐DOPA injection in Sprague–Dawley rats. J of Neurochemistry 20 March 2008
https://doi.org/10.1111/j.1471-4159.2008.05358.x
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1471-4159.2008.05358.x
Tecchio F, Assenza G, Zappasodi F, Mariani S, Salustri C, Squitti R. Glutamate-mediated primary somatosensory cortex excitability correlated with circulating copper and ceruloplasmin. Int J Alzheimers Dis. 2011;2011:292593. doi: 10.4061/2011/292593. Epub 2011 Nov 21. PMID: 22145081; PMCID: PMC3227495.
https:// elsewhere?
Irreversible inhibition is different from irreversible enzyme inactivation.
Jimenez K, Kulnigg-Dabsch S, Gasche C. Management of Iron Deficiency Anemia. Gastroenterol Hepatol (N Y). 2015 Apr;11(4):241-50. PMID: 27099596; PMCID: PMC4836595.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836595/
Anemia is associated with chronic fatigue, impaired cognitive function, and diminished well-being.
Park HY, Jeon HJ, Bang YR, Yoon IY. Multidimensional Comparison of Cancer-Related Fatigue and Chronic Fatigue Syndrome: The Role of Psychophysiological Markers. Psychiatry Investig. 2019 Jan;16(1):71-79. doi: 10.30773/pi.2018.10.26. Epub 2019 Jan 7. PMID: 30605994; PMCID: PMC6354035.
http://psychiatryinvestigation.org/journal/view.php?doi=10.30773/pi.2018.10.26
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354035/
Conclusion
Findings indicate that different pathophysiological mechanisms underlie CFS and CRF. Inflammatory marker and HRV may be potential biomarkers for distinguishing two fatigue syndromes and frontal EEG parameters may be quantitative biomarkers for CFS.
Keywords: Fatigue, Cancer, Biomarkers, Electrocardiography, Electroencephalography
INTRODUCTION
There is a high prevalence of cancer-related fatigue (CRF), which is prolonged fatigue after treatment for cancer, in this population [1]. However, the pathophysiological mechanisms underlying CRF are not yet clearly understood. Most criteria for CRF consist of core characteristics that include complaints of fatigue that result in functional impairments accompanied by cognitive and sleep disturbances [2,3]. These components overlap with the diagnostic criteria for chronic fatigue syndrome (CFS) [4], which is characterized by intense persisting fatigue that limits function. Thus, it has been proposed that similar mechanisms, including inflammation and perpetual deconditioning, underlie these two fatigue syndromes [5]. Still, the pathophysiology of CFS remains elusive, immune and neuroendocrine dysfunction and psychiatric disorders may be related to this disorder [6]. Additionally, central nervous system (CNS) abnormalities appear to be involved in the pathophysiology of CFS however, the results have been inconclusive [4].
Despite the similarities of these two fatigue syndromes, few studies have specifically compared them. Servaes et al. [5] reported that CFS patient exhibit a more severe degree of fatigue and pain than patients with CRF. Previous study reported the associations between cognitive function and the CRF [7] and CFS [8].
Fibro symptoms:
Goldenberg DL. Diagnosing Fibromyalgia as a Disease, an Illness, a State, or a Trait? Arthritis Care Res (Hoboken). 2019 Mar;71(3):334-336. doi: 10.1002/acr.23727. Epub 2019 Feb 6. PMID: 30724034.
https://onlinelibrary.wiley.com/doi/full/10.1002/acr.23727
-
Exercise:
Nazıroğlu M, Akkuş S, Soyupek F, Yalman K, Çelik Ö, Eriş S, Uslusoy GA. Vitamins C and E treatment combined with exercise modulates oxidative stress markers in blood of patients with fibromyalgia: a controlled clinical pilot study. Stress. 2010 Nov;13(6):498-505. doi: 10.3109/10253890.2010.486064. Epub 2010 Jul 28. PMID: 20666654.
-
Yoga massage stress anxiety social support & meditation
Adler-Neal AL, Zeidan F. Mindfulness Meditation for Fibromyalgia: Mechanistic and Clinical Considerations. Curr Rheumatol Rep. 2017 Sep;19(9):59. doi: 10.1007/s11926-017-0686-0. PMID: 28752493; PMCID: PMC5693231.
Fibromyalgia is chronic pain condition characterized by widespread “aching” pain and is often accompanied by tenderness in 18 pre-specified bodily locations [2]. It is often accompanied by sleep disturbances and fatigue [3, 4].
-
Arcos-Carmona IM, Castro-Sánchez AM, Matarán-Peñarrocha GA, Gutiérrez-Rubio AB, Ramos-González E, Moreno-Lorenzo C. Efectos de un programa de ejercicios aeróbicos y técnicas de relajación sobre el estado de ansiedad, calidad del sueño, depresión y calidad de vida en pacientes con fibromialgia: ensayo clínico aleatorizado [Effects of aerobic exercise program and relaxation techniques on anxiety, quality of sleep, depression, and quality of life in patients with fibromyalgia: a randomized controlled trial]. Med Clin (Barc). 2011 Oct 8;137(9):398-401. Spanish. doi: 10.1016/j.medcli.2010.09.045. Epub 2011 Feb 22. PMID: 21345470.
https://www.elsevier.es/es-revista-medicina-clinica-2-linkresolver-efectos-un-programa-ejercicios-aerobicos-S0025775310010444
Conclusions: The combination of aerobic exercise program and progressive relaxation techniques contribute to improve night rest, trait anxiety and quality of life in patients with fibromyalgia
-
Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014 Apr 16;311(15):1547-55. doi: 10.1001/jama.2014.3266. PMID: 24737367
-
Grey Matter Changes
Pomares FB, Funck T, Feier NA, Roy S, Daigle-Martel A, Ceko M, Narayanan S, Araujo D, Thiel A, Stikov N, Fitzcharles MA, Schweinhardt P. Histological Underpinnings of Grey Matter Changes in Fibromyalgia Investigated Using Multimodal Brain Imaging. J Neurosci. 2017 Feb 1;37(5):1090-1101. doi: 10.1523/JNEUROSCI.2619-16.2016. Epub 2016 Dec 16. PMID: 27986927; PMCID: PMC6596849.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596849/
https://www.jneurosci.org/content/37/5/1090.long
Chronic pain patients present with cortical gray matter alterations, observed with anatomical magnetic resonance (MR) imaging. Reduced regional gray matter volumes are often interpreted to reflect neurodegeneration, but studies investigating the cellular origin of gray matter changes are lacking.
-
Jezek M, Geilfus CM, Mühling KH. Glutamine synthetase activity in leaves of Zea mays L. as influenced by magnesium status. Planta. 2015 Dec;242(6):1309-19. doi: 10.1007/s00425-015-2371-8. Epub 2015 Jul 23. PMID: 26202737.
https://link.springer.com/article/10.1007/s00425-015-2371-8
Magnesium (Mg) is an integral component of the enzyme glutamine synthetase (GS), having both a structural and a catalytic role. Moreover, Mg is relevant for the post-translational regulation of the GS.
-
Iron deficiency:
Ortancil O, Sanli A, Eryuksel R, Basaran A, Ankarali H. Association between serum ferritin level and fibromyalgia syndrome. Eur J Clin Nutr. 2010 Mar;64(3):308-12. doi: 10.1038/ejcn.2009.149. Epub 2010 Jan 20. PMID: 20087382.
https://www.nature.com/articles/ejcn2009149
-
Substantiates one cause of psych w/fibro
Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH, Chen TJ, Bai YM. Association between psychiatric disorders and iron deficiency anemia among children and adolescents: a nationwide population-based study. BMC Psychiatry. 2013 Jun 4;13:161. doi: 10.1186/1471-244X-13-161. PMID: 23735056; PMCID: PMC3680022.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680022/
-
Depression low ferritin
The study implies a possible association between depression and decreased ferritin level before the occurrence of anemia.
Vahdat Shariatpanaahi, M., Vahdat Shariatpanaahi, Z., Moshtaaghi, M. et al. The relationship between depression and serum ferritin level. Eur J Clin Nutr 61, 532–535 (2007). https://doi.org/10.1038/sj.ejcn.1602542
https://www.nature.com/articles/1602542
-
Kim J, Wessling-Resnick M. Iron and mechanisms of emotional behavior. J Nutr Biochem. 2014 Nov;25(11):1101-1107. doi: 10.1016/j.jnutbio.2014.07.003. Epub 2014 Aug 2. PMID: 25154570; PMCID: PMC4253901.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253901/
Serotonin, dopamine & norepinephrine alterations low iron.
-
-
-
-
Gómez-Gómez ME, Zapico SC. Frailty, Cognitive Decline, Neurodegenerative Diseases and Nutrition Interventions. Int J Mol Sci. 2019 Jun 11;20(11):2842. doi: 10.3390/ijms20112842. PMID: 31212645; PMCID: PMC6600148.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600148/
-
Magnesium
Thomas J. Romano (Private Practice) & John W. Stiller (1994) Magnesium Deficiency in Fibromyalgia Syndrome, Journal of Nutritional Medicine, 4:2, 165-167, DOI: 10.3109/13590849409034552
https://www.tandfonline.com/doi/abs/10.3109/13590849409034552
Compared to reference laboratory and OA controls, FS patients had significantly lower RBC Mg levels. The plasma Mg levels of FS patients were no different than the reference laboratory or OA controls.
Need J&J&W et al to say RBC Mg means deficient to substantiate this.
Here!
Rude RK, Stephen A, Nadler J. Determination of red blood cell intracellular free magnesium by nuclear magnetic resonance as an assessment of magnesium depletion. Magnes Trace Elem. 1991-1992;10(2-4):117-21. PMID: 1844544.
https://pubmed.ncbi.nlm.nih.gov/1844544/
In 3 weeks from normal: These data suggest that determination of RBC Mg2+ may be used to reflect intracellular Mg status
-
Nuytten D, Van Hees J, Meulemans A, Carton H. Magnesium deficiency as a cause of acute intractable seizures. J Neurol. 1991 Aug;238(5):262-4. doi: 10.1007/BF00319737. PMID: 1919610.
-
Jezek M, Geilfus CM, Mühling KH. Glutamine synthetase activity in leaves of Zea mays L. as influenced by magnesium status. Planta. 2015 Dec;242(6):1309-19. doi: 10.1007/s00425-015-2371-8. Epub 2015 Jul 23. PMID: 26202737.
https://link.springer.com/article/10.1007/s00425-015-2371-8
Magnesium (Mg) is an integral component of the enzyme glutamine synthetase (GS), having both a structural and a catalytic role. Moreover, Mg is relevant for the post-translational regulation of the GS.
--
Botturi A, Ciappolino V, Delvecchio G, Boscutti A, Viscardi B, Brambilla P. The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients. 2020 Jun 3;12(6):1661. doi: 10.3390/nu12061661. PMID: 32503201; PMCID: PMC7352515.
Depression fibro
-z
Medical Hypotheses
Volume 140, July 2020, 109676
The art of suicidal molecular seduction for targeting drug resistance
Author links open overlay panelMohammad HassanMoshafiaArdavanAbiric1
Covalent inhibitors bind to their targets via a biologically permanent bound with their cognate receptor and therefore display more potent inhibiting characteristics. Suicide inhibitors or mechanism-based inhibitors are one of the covalent inhibitors, which require a pre-activation step by their targeting enzyme. This step accrues their selectivity and specificity with respect to other covalent inhibitors. After that pre-activation step, they produce an analogue of the transition state of the catalytic enzyme, which is practically incapable of dissociating from the enzyme.
--
Gómez-Gómez ME, Zapico SC. Frailty, Cognitive Decline, Neurodegenerative Diseases and Nutrition Interventions. Int J Mol Sci. 2019 Jun 11;20(11):2842. doi: 10.3390/ijms20112842. PMID: 31212645; PMCID: PMC6600148.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600148/
Not sure if needed
--
Martinc B, Grabnar I, Vovk T. Antioxidants as a preventive treatment for epileptic process: a review of the current status. Curr Neuropharmacol. 2014 Dec;12(6):527-50. doi: 10.2174/1570159X12666140923205715. PMID: 25977679; PMCID: PMC4428026.
Not needed?
