Because magnesium is used in so many ways in the body, there is a buffet of systems for the body to choose between in deciding where to put an insufficiency or deficiency. A wandering eye[1], an inability to tell blue from green[2], depression[3], excessive clotting[4], high blood pressure, calcification of the arteries and heart, and increased diabetes[5][9], spasms and cramped muscles[6], gastrointestinal issues[7], an inability to tolerate ciprofloxacin[8], and a host of cardiovascular symptoms[5][9] can be caused by low magnesium.

A 2018 study, Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis (James J DiNicolantonio, James H O’Keefe, and William Wilson)[9], states at the start of the abstract, 

"Because serum magnesium does not reflect intracellular magnesium, the latter making up more than 99% of total body magnesium, most cases of magnesium deficiency are undiagnosed."


Not only can parole syndrome cause a lifelong magnesium deficiency, but it seems to be the one of the most common deficiency caused by medications. Since magnesium increases potassium, its interaction with certain diuretics and blood pressure medications can be problematical.


Once a person has started taking medication for these conditions, take taking magnesium can make the condition reverse itself dangerously, going to the opposite extreme, low blood pressure or insufficient clotting has examples. This makes it unsafe for the aware patient to do self treatment,, but if the lab test show normal, it is going to be difficult for a patient to get help from their doctor to correct the insufficiency or deficiency while reducing various medications according to reducing symptoms. Most patients will be unaware, as the doctor is unaware, and continue to take medications for condition which could be more comprehensively treated using a nutritional supplement or, if the condition is minor enough, a change of diet.

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A wandering eye[1]


, an inability to tell blue from green[2]



4 Trang T Vu et al. Thromb Haemost. Zinc: an important cofactor in haemostasis and thrombosis. 2013 Mar;109(3):421-30.

doi: 10.1160/TH12-07-0465. Epub 2013 Jan 10.
PMID: 23306381
DOI: 10.1160/TH12-07-0465


5 Uwe Gröber's Magnesium and Drugs, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539869/#!po=62.5000 with an excellent image of ways that drugs interfere with nutrient levels in the body, and a table specific to Magnesium.

Lists arterial calcification, hypertension, insulin resistance, atherosclerosis, heart failure, and thrombosis, and describes disorders of magnesium metabolism as a principal, under-recognized, "driver" of cardiovascular disease. Pairs well with [9].


[], spasms and cramped muscles[6]


, gastrointestinal issues[7],


 an inability to tolerate ciprofloxacin[8]



9 James J DiNicolantonio, James H O’Keefe, and William Wilson, Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis, Open Heart. 2018; 5(1): e000668corr1. doi: 10.1136/openhrt-2017-000668corr1

PMCID: PMC5888441

PMID: 29634047

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