Under construction - Citations and links needed.
Most medications drain nutrients. Among the ways are:
- blocking absorption (reducing acid: calcium and iron)
- changing the nutrient (some antifolates)
- encouraging removal (lithium and sodium)
- antigonizing (copper and zinc)
- simply using it in the process of drug action in the body (magnesium as a component of enzymes used in greater quantity)
- temporary sequestering in the cells away from the plasma (dopamine sequesters iron in cells)
- removal from cells, increasing plasma concentration at the expense of the nutrients in the cells, potentially causing false lab results (adrenaline allows calcium to move more easily in and out of cells; with cortisol preventing reuptake of estrogen, calcium is more easily depleted once in plasma)
Magnesium is one of the most common, as per medical literature.
Add Link.
Both magnesium and zinc are necessary for the blood to clot properly, specifically to not over-clot. Reduce either, clotting goes up. Suggestions of what not to take with blood thinners includes magnesium - it could be better to test, and take extra magnesium and see whether a blood thinner is still necessary. Per
Cite
, insufficient magnesium does not show in plasma until after insufficient in cells, possibly worse for some patience than others due to genetic adaptation.
Therefore, both from ancestrial epigenes, and after years of low a low-level chronic insufficiency, a patient's body may have adapted to so that some cells are shorted in preference to the plasma so that sufficient is available to the muscles and other more immediate needs. (This could explain why many drugs affect sexual desire or capability, because sexual function is only used intermittently, and other organs and systems are used constantly or at least far more often.)
Also, lab draws are often either stressful for some patients, or drawn (such as at the ER or when sick) when the patient is under emotional or chemical stress (the reason why diabetics' blood sugars go up when ill.) With stress chemicals, the blood will optimize oxygen, glucose and nutrients. (I call this, "Preparing to fight that cave bear.") Thus, highly stressed patients may not show low levels in laboratory blood draws, even if they have deficiencies in the cells.
Cite.
When someone is suspected of having a magnesium or zinc deficiency, from mulitple medications, Wilson's disease, Pyrrole syndrome[4], copper overload[4], or possibly some autistics or Aspergers[5] (because zinc has been found beneficial, and beneficial could easily mean being deficit), magnesium shortage should be suspected, and treated accordingly, to reduce the risk of clotting in the brain and having a stroke if their zinc levels reduce, due to the Coronavirus.
For people who start clotting, or people on multiple medications, doctors should consider increasing magnesium as well as zinc, through nutrition as well as supplementation, if it is deemed safe and worthwhile. Decreasing vitamin K might be another dietary improvement, since it is part of clotting.
Summation:
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Links & references:
Association between Serum Magnesium Levels and Depression in Stroke Patients
Aging Dis. 2016 Dec; 7(6): 687–690.
Published online 2016 Dec 1. doi: 10.14336/AD.2016.0402
PMCID: PMC5198859
PMID: 28053818
Yingying Gu, Kai Zhao, Xiaoqian Luan, Zhihua Liu, Yan Cai, Qiongzhang Wang, Beilei Zhu,* and Jincai He*
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198859/
> below, fibrin and fibrogen relate to clotting; magnesium creates a better clotting factor; with the above, this links low magnesium to clotting and one type of stroke, and to depression, and with links at the top, to nutritional deficiencies from medications. Any questions?
Effect of magnesium on fibrin formation from lower molecular weight (LMW) fibrinogen
https://pubmed.ncbi.nlm.nih.gov/11153893/
Lipinski B, Lipinska I. Effect of magnesium on fibrin formation from lower molecular weight (LMW) fibrinogen. Magnes Res. 2000;13(4):233-237.
© Deborah Barges, July 2020, reprintable and usable per open access rules.