Zinc has been found to seem to act with a gentle braking action on the immune system, explained in Zinc helps against infection by tapping brakes in immune, response://www.sciencedaily.com/releases/2013/02/130207131344.htm
It seems that it regulates it both down and up.
Cortisol reduces inflammation, even better when aided by vitamin D.
Histamines, which increase inflammation, nevertheless help zinc in the same way to remove free radical copper from the body. Choosing a diet to minimize copper to reduce the usefulness of histamine will encourage the body to stop producing as much, giving a benefit of reduced inflammation.
By this model, it would be possible that increasing vitamin D, reducing copper (and with it, the need for extra histamine), and by increasing zinc, we could mitigate cytokine storms. Could it be something as simple as that? Doubtful. But helpful? For some people, quite likely.
Again, anything to give people an edge, until a vaccine or cure is available.
However, people with hypomethylation (aka undermethylation) will also need a methyl donor (methylprednisone is being found effective, possibly for that reason as well.)
They may benefit from the other methylation-targetted nutrients, as well; lists vary, possibly as the needs of different populations might vary, by genetic strains or epigenetic regional differences such as heat or diet. Among them are:
· Betain
· l-methionine
· NAC ( n-acetyl cysteine)
· B6
· Choline
· Methylfolate (not for people who are low in zinc! - So, not for people still recovering from coronavirus.)
Unsurprisingly, the list is heavy on methyl donors. Not every methyl donor is alike - MSM has been found not to be able to act directly as a methyl donor - although over time, by supplying methyl to body tissues which could then be broken apart and stolen from, it could have a benefit over a longer haul, if one doesn't mind the waste of both time and energy, which one certainly does during a cytokine storm.
Since different people have different nutrient shortages after a virus and a diet different from what their body is used to, one size won't fit all equally.
Unless the blood test show that copper has been used to steal the zinc from the immune system by some action of coronavirus, the chances are that copper is high; this is normal when the needs of the immune system to fight virus prioritize the immune system over copper removal from the body.
It is possible that the bodies of some people with cytokine storms starts prioritising removal of copper at the end of Coronavirus before it starts prioritizing it for methylation, or for limiting the immune system. For these people, zinc will have a strong effect. Those people have likely already recovered, if they weren't taken off of zinc too soon to avoid an overdose, and overdepletion of copper (among other things.)
After an illness, if copper is high enough, iron may be lowered - one cause for chest pain and shortness of breath. Because the body under stress uses cortisol to demineralize amino acids, the serum level of iron may not be as accurate an indicator of iron levels, but where low, or at the botyom of range, it could be supplemented - after reducing copper further, with zinc or a short and low dose of one of the other two Wilson's disease medications.
© Deborah Barges, July 2020, reprintable and usable per open access rules.