Folic Acid


Intentional antifolates are used to treat conditions such as cancer and psoriasis. 

Incidental antifolates interfere with B9 as a side effect of the drug, and though not intentionally used to treat a condition, can still lead to low B9.

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Lists of medications which deplete folic acid:

Beaufort Hospital

https://www.bmhsc.org/health-and-wellness/education-support/health-library/article?productId=107&pid=33&gid=000722

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St Luke's Hospital 

https://www.stlukes-stl.com/health-content/medicine/33/000722.htm

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Penn State Hershey Medical Center

http://pennstatehershey.adam.com/content.aspx?productid=107&pid=33&gid=000722

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Folic acid deficiency linked to mental illness, and used as treatment for improving mental illness:

MTHFR gene

Methylenetetrahydrofolate reductase and psychiatric diseases    

Transl Psychiatry. 2018; 8: 242. Published online 2018 Nov 5. doi: 10.1038/s41398-018-0276-6


PMCID: PMC6218441

PMID: 30397195

Lin Wan,1 Yuhong Li,1 Zhengrong Zhang,2 Zuoli Sun,2 Yi He,2 and Rena Li1,2,3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218441/

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NAMI St. Louis › 2016/11PDF

Folate and Mental Illness FACT SHEET - NAMI St. Louis - a download


https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.namistl.org/wp-content/uploads/sites/144/2016/11/folate_factsheet.pdf&ved=2ahUKEwic9oXJ_8bpAhVVCM0KHZTJDegQFjAMegQIAxAB&usg=AOvVaw2li76rd3U7WRKTGGhvPYxJ

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Medscape Psychiatry & Mental Health eJournal [TM]

Nutrition and Depression: The Role of Folate


https://www.medscape.com/viewarticle/431514_4


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